Interaction graphs

We present KiPhyNet, an interactive, user-friendly application that facilitates the simulation and visualization of advection-dispersion transport in three-dimensional (3D) microvascular networks, biochemical exchange, and metabolic reaction in the tissue layer surrounding the vasculature. KiPhyNet provides the functionality to assimilate multi-omics data from clinical and experimental studies as well as vascular data from imaging studies to investigate the role of structural changes in vascular topology on the functional response of the tissue. KiPhyNet is implemented in python based on Apache web server using MATLAB as the simulator engine. With the network topology, its biophysical attributes, and the values of the kinetic and transport constants as inputs, a user can use our application to simulate and view the simulation results; interactively examine the results of steady-state velocity and pressure fields and dynamic concentration fields. Taken together, KiPhyNet provides barrier-free access to perform time-course simulation experiments by building multi-scale models of microvascular networks in physiology.